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Wealth Building Strategies

Killing Cancer One Gene at a Time

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Posted by Jon Markman - Money and Markets

on Tuesday, 21 February 2017 06:31

You probably haven’t heard about precision medicine. That’s fine, it wasn’t even possible ten years ago.

But now we’re entering the new Gilded Age — and suddenly researchers are using it to fight many deadly diseases, including brain cancer in kids.

Scientists at Dana Farber, a Harvard-affiliated research group, and the Boston Children’s Blood Disorders and Cancer Center, recently sequenced tumor samples from 200 children with brain cancer, Forbes reported.

Screen Shot 2017-02-21 at 6.33.06 AMWhat they found was astounding: More than half the children exhibited genetic abnormalities that could influence how the disease was treated.

“The reason we did this trial was that brain tumors are a leading cause of death in children, and the treatments that we and everyone else use are decades old – radiation and chemo,” writes Pratiti Bandopadhayay, a pediatric neuro-oncologist at Dana-Farber/Boston Children’s in the medical journal Neuro-Oncology. “Our approach to try to improve on that is to target the individual tumors of each child.”

That’s the key. Precision medicine promises to change health sciences by using data analytics and what we know about ourselves to tailor personal therapies and treatments.

In this way, precision medicine is the perfect symbol of the New Gilded Age. It grew out of the awesome advances in cloud computing. It touched medicine and changed what researchers thought to be possible. Without that, neither genome sequencing nor bespoke drug discovery would be possible. Certainly it would not have been possible for doctors to dream about developing treatments based on the patient’s individual biology.

In theory, it all seems simple enough, even logical. Getting to this point has been a bit more complex.



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Wealth Building Strategies

Want To Find The Opportunities? Follow The Sentiment

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Posted by Frank Holmes - US Global Investors

on Friday, 17 February 2017 08:48

holmes021617-1On Monday I had the opportunity to attend a conference at Goldman Sachs’ Dallas office. Among the dozens of money managers and investors who attended, a combined $1 trillion in assets was represented. The speakers were numerous, from famed economist Jan Hatzius, Goldman’s head of global economics, to Jeff Currie, global head of commodities research. Everyone was exceedingly smart and articulate, and I left the conference feeling recharged with much to think about.

One of the most fascinating takeaways was Goldman’s increased use of sentiment analysis tools. Basically what this means is sophisticated software trawls the internet in real time for public attitudes and opinions on companies, products, sectors, industries, countries—you name it. Sources can include press releases, news stories, earnings calls, blogs, social media and more. All of this data is gathered and analyzed, giving quants and other highly sophisticated investors a better idea of where tomorrow’s opportunities lie.

We have experience gauging sentiment using platforms designed by Meltwater and ScribbleLive, and I was pleased to see our efforts validated.

Goldman’s preferred system is Stanford’s CoreNLP, which is able to break down and analyze sentences in a number of different ways (and different languages to boot). Below is just a sampling of what the process looks like.   



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Wealth Building Strategies

P.T. Barnum's Three Tips for Building Wealth

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Posted by P. T. Barnum (1810 – 1891)

on Thursday, 16 February 2017 09:15

pt-barnumP. T. Barnum (1810 – 1891) was an American showman, businessman, and entertainer, who founded what became the Ringling Bros. and Barnum & Bailey Circus. He became a very wealthy man and he shares some advice on how to acquire wealth in his book “The Art Of Money Getting”. Here are three of the tips he shares in his book:

Be Frugal

“Wear the old clothes a little longer if necessary; dispense with the new pair of gloves; mend the old dress, live on plainer food if need be; so that, under all circumstances, unless some unforeseen accident occurs, there will be a margin in favor of the income. A penny here, and a dollar there, placed at interest, goes on accumulating, and in this way the desired result is attained.”

Choose Work You Enjoy

“The safest plan, and the one most sure of success for the young man starting in life, is to select the vocation which is most congenial to his tastes . . . We are all, no doubt, born for a wise purpose . . . Unless a man enters upon the vocation intended for him by nature, and best suited to his peculiar genius, he cannot succeed.”

Be Cautious and Bold

“Among the maxims of the elder Rothschild was one, all apparent paradox: ‘Be cautious and bold’. This seems to be a contradiction in terms, but it is not, and there is great wisdom in the maxim. It is, in fact, a condensed statement of what I have already said. It is to say: ‘you must exercise your caution in laying your plans, but be bold in carrying them out.’ A man who is all caution, will never dare to take hold and be successful; and a man who is all boldness, is merely reckless and will eventually fail.”

...related: Seven Essential Ways to Build Wealth



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Wealth Building Strategies

Gold Intermediate Cycle Update

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Posted by Surf City

on Wednesday, 15 February 2017 07:25

NOTHING is certain or guaranteed in Markets.... ever. Anyone who tells you otherwise is a charlatan.

That said, within Bressert's Cycle framework the norm is that a new Intermediate Cycle in any asset should test or breach the Intermediate Cycle downtrend before topping and those are my expectations based on my current analysis on both Gold and the USD.

With that as background, my Gold chart shows these expectations.



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Wealth Building Strategies

The most successful investment strategy in the world

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Posted by Tim Price via Simon Black's Sovereign Man

on Friday, 10 February 2017 13:30

2017 02 10 featured imageEducation is a BIG part of a having a Plan B… especially when it comes to money.

In light of the obvious risks that we discuss on a regular basis, safeguarding (and growing) our savings is absolutely critical.

Finance can be a little bit scary and seem quite complicated at first.

No one comes out of the womb a financial expert. And they certainly don’t teach this stuff in a government-controlled public school system.

But just like speaking a foreign language or learning to drive, knowing how to properly manage money is a SKILL.

And it’s one that can be learned. By ANYONE.

The difference between knowing versus NOT knowing how to manage money can have an EXTRAORDINARY impact on your life.

Simply being able to generate an extra 1% to 2% annual return on your investments can add up to hundreds of thousands of dollars in extra wealth over 20-30 years.

As with any other skill, learning about finance takes some time and patience. But the reward is extraordinary.

I wanted to pass along an email today that highlights key characteristics of the world’s most successful long-term investment strategy.

It was written by my friend and colleague Tim Price, a UK-based wealth manager who is a disciplined master of “value investing”.

This strategy is absolutely worth understanding. Learning it can truly have an enormous impact on your life.

— From Tim: —

Successful investing involves having an edge.

And if you do not know what your edge is, you do not have one.

So which investment strategy actually works?

...continue reading HERE



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